Filamin A Stabilizes Fc RI Surface Expression and Prevents Its Lysosomal Routing
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چکیده
منابع مشابه
Fc receptor transmembrane domains: role in cell surface expression, chain interaction, and phagocytosis
We constructed chimeric receptors to dissect the role of the transmembrane (TM) domain in cell surface expression of and phagocytosis by the chain–dependent Fc receptors Fc RIIIA and Fc RI. Fc R chimeras containing the TM and cytoplasmic (CY) domains of the chain were expressed on the cell surface and mediated an efficient phagocytic signal. In contrast, chimeras containing the Fc RIIIA TM were...
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In mouse mast cells, both Fc e RI and Fc g RIII are abg 2 tetrameric complexes in which different a chains confer IgE or IgG ligand recognition while the signaling FcR b and g chains are identical. We used primarily noninvasive techniques (changes in body temperature, dye extravasation) to assess systemic anaphylactic responses in nonanesthetized wild-type, Fc e RI a chain 2 / 2 and FcR g chain...
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تاریخ انتشار 2008